New research reveals that people who come off popular weight-loss injections like Mounjaro or Wegovy tend to recover reduced body mass far faster than those who end traditional diet and exercise programs.
Research printed in a prominent health publication points out that while obese people often shed substantial amounts of their total mass while on the medication, the mass returns at an estimated rate of nearly a kilo each month once they quit.
"People using such treatments need to be cognizant of the risk of rapid weight regain when the medication ends," warns lead investigator Dr. Susan Jebb.
That rate of regain means a reversion to original weight in about one and a half years.
Weighing Approaches
The research, which reviewed 37 of studies involving thousands of patients, contrasted the results of the injectable medications with other pills.
The team note that people who shed pounds through lifestyle changes alone usually experience a less rapid creep back—perhaps 100 grams monthly—post-intervention.
The Reason for the Rapid Rebound
Doctors suggest the mechanism of the drugs explains the heightened regain.
These medications mimic a body's own chemical called glucagon-like peptide-1, which controls feelings of fullness.
"Sustained high doses of the hormone levels far above than normal could lead to the body to produce less of its own natural hormone, and could diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this GLP-1 'fix' means hunger is no longer kept in check, making binge eating a significant risk."
A Lifelong Issue?
Medical guidelines suggest the injections for individuals with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, given the high risk of relapse, the treatment might need to be long-term.
This opinion is reinforced by pharmaceutical companies, who say that the findings "highlight the long-term nature of obesity," akin to managing conditions like diabetes.
User Experiences
People who have stopped the jabs report a intense return of hunger.
"It was like something flipping and you become ravenous," said a patient.
The struggle is compounded if patients have not adopted lasting dietary or behavioural changes during treatment.
Widespread Adoption
Figures show that millions of people in the UK have tried weight-loss jabs in the last 12 months, with desire being substantial.
- Use is more common among females than males.
- The 40s and 50s age group shows the greatest level of interest.
- Many access the medications through private prescriptions rather than public health services.
In conclusion, researchers caution that while the jabs are effective tools for weight loss, they are not a permanent cure and maintained weight loss hinges on ongoing behavioural support.
